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  1. Install Monit in /usr/local/monit:

The Monit installer package for macOS will automatically install Monit in /usr/local/monit for you. Alternatively, you can build Monit from source: 

./configure --prefix=/usr/local/monit \
  --mandir=/usr/local/monit/man/ \
  --sysconfdir=/usr/local/monit/conf/ 
make
make install
mkdir -p /usr/local/monit/conf/ && cp monitrc /usr/local/monit/conf/
  1. Edit startup configuration:

/Library/LaunchDaemons/com.tildeslash.monit.plist 

<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE plist PUBLIC "-//Apple//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
<plist version="1.0">
<dict>
      <key>Label</key>             <string>com.tildeslash.monit</string>
      <key>ProcessType</key>       <string>Adaptive</string>
      <key>WorkingDirectory</key>  <string>/usr/local/monit</string>
      <key>Disabled</key>          <false/>
      <key>RunAtLoad</key>         <true/>
      <key>LaunchOnlyOnce</key>    <false/>
      <key>ProgramArguments</key>
      <array>
              <string>/usr/local/monit/bin/monit</string>
              <string>-I</string>
              <string>-c</string>
              <string>/usr/local/monit/conf/monitrc</string>
      </array>
</dict>
</plist>
  1. Load: 
launchctl load -w /Library/LaunchDaemons/com.tildeslash.monit.plist